Lonza will help you determine the most suitable chemical and physical form of an API. The selection involves the screening and characterization of chemical forms and the associated polymorphs. Every molecule has a different propensity for polymorphism and forms hydrates and solvates.
Selecting a lead solid involves chemical forms (salts, cocrystals, solvates) and associated polymorphs. The molecule's physicochemical properties and TPP dictate the need for screening salts, cocrystals, or bioavailability-enhanced formulations and the key properties of any solid form:
- Solubility
- Dissolution rate
- Manufacturability
- Stability
- & more
Effective form screening and selection are critical for early and late-stage development to mitigate risks and strengthen Intellectual Property (IP) claims.
Get access to world-leading equipment and expertise that will quickly study the various solid forms of your molecule, so you can enhance bioavailability and accelerate your development timeline.
- Characterization
- Cocrystal screen
- Hydrate mapping
- Single-crystal XRD
- Stable form screen
- Primary salt screen
- Secondary salt screen
- Preformulation screen
- Enantiomeric screening
- Primary polymorph screen
- PXRD method development
- Amorphous solid dispersions
- Secondary polymorph screen
- ASAP and traditional stability
- Salt developability assessment
- Stable form developability assessment
