Expression Technologies

The Lonza in Your Lab^® offering provides flexibility to either take our expression technology platforms into your lab under license or let Lonza do it for you at any stage in the process.

Our technology platforms available to license include the GS Gene Expression System® mammalian platform including the GS piggyBac® transposon system,  the GS Discovery® transient expression platform, the XS Technologies® microbial platform, and HEK293 cells plus patented vector technologies for AAV production.

Proprietary technology and expertise are at the core of our expression technology platform portfolio.

Strengthen your path from sequence to clinic by pairing our Expression Technologies with Early Development Services (EDS). EDS provides early manufacturability, immunosafety, and expression insights, helping you optimize candidates and reduce risk. These early‑stage insights and prototype materials further equip your program for a smoother transition toward IND filing and subsequent clinical development. 

Developing protein drugs that depend upon a mammalian or microbial process poses unique challenges that increase as you move from development to commercial scale. To accelerate production, developers need an established, efficient and regulatory-compliant expression technology that scale quickly and reproducibly to meet future needs. With our portfolio of mammalian and microbial expression platforms and expertise, we can help you develop such robust processes.

GS Gene Expression System® technology supports the optimal expression and production of monoclonal antibodies, complex proteins and next-generation biologics.

• The complete system includes host cell lines, vectors, access to optimized media and feeds, and process expertise
• The GS Xceed® gene expression system is the industry-recognized host cell line for stable high titers and productivity
• The GS Effex® cell line is Lonza’s latest player in the development of antibody immunotherapies. All you love from the GS Xceed® gene expression system, now fucose-free
• GS piggyBac® transposon technology is now part of the system and can help to overcome the challenge of complex protein expression
• The GS Discovery® transient expression system supports high-titer transient expression for early-stage development.

Learn more about GS Xceed® Gene Expression System or contact our experts. 

Our XS Technologies® platform includes Pichia pastoris and Escherichia coli expression systems. With a selection of microbial multi-host systems, you can address a diverse range of molecules.

• XS® Pichia expression system is the best in class for complex, non-glycosylated protein production
• XS® E.coli expression system is one of the most trusted and established organisms for the expression of simple to moderately complex biologics

Learn more about XS Technologies® platform or contact our experts.

Solve heavy-light chain mispairing whilst retaining closer-to-nature antibody structure and standard downstream purification with bYlok® technology.

Learn more about bYlok® Bispecific Pairing Technology.