Mastering chemistry, manufacturing, and control complexities for in vivo CAR-T therapies, including messenger and circular RNAs, represents a new challenge for drug development. Moving from “simple” mRNA vaccines with “naked” LNPs to complex mRNA therapeutics delivered by targeted LNPs demands more than new technologies - it requires a deep understanding of quality requirements, delivery challenges, and opportunities for an innovative process design.
In this on-demand webinar we explore the critical factors that define success for in vivo CAR-T, from linker selection and conjugation strategies to LNP encapsulation and sterile filtration. It will also address some of the unique analytical challenges. You will gain a clear understanding of the key challenges and emerging opportunities influencing the future of in vivo CAR-T therapies.
Gain insight on:
- The understanding of quality requirements for the development and the manufacturing of complex RNA therapies
- How to design an innovative strategy from development to IND for your RNA in vivo CAR-T therapies
- How to address the delivery challenges from a quality and reproducibility perspective
- Identifying the major challenges in the design and scale up of your in vivo CAR-T therapies
